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Main phospholipid (MPL) of Thermoplasma acidophilum (>50% pure)/热原体嗜酸乳杆菌主要磷脂(MPL)

Specifications

  • Catalog #:1303-2

  • Scientific Name:Main phospholipid (MPL) of Thermoplasma acidophilum (>50% pure)

  • Common Name:Purified MPL of Thermoplasma acidophilum (>50% pure)

  • Empirical Formula:C95H188O16P

  • SDS:View Safety Data Sheet

  • Data Sheet:View Data Sheet

  • Formula Weight:1618

  • Unit:50 mg

  • Source:natural

  • Purity:>50%

  • Analytical Methods:TLC

  • Natural Source:archaebacteria

  • Solubility:chloroform/methanol, 2:1; hexane/2-propanol/DI water, 30:40:5

  • Physical Appearance:solid

  • Storage:4-8℃

  • Dry Ice:No

  • Hazardous:No

Description

Application Notes:

热原体嗜酸乳杆菌主要磷脂(MPL)为高纯度四醚单糖磷脂,是嗜酸热浆菌的主要磷脂(MPL)。 它包含一个甘油磷酸和一个通过四醚链连接的谷糖基吡喃糖苷单糖。 MPL在很大程度上是嗜酸T. ophilum在低pH(1-2)和高温(55- 59°C)下存活的原因1,几乎占总脂质的一半 MPL可用于制备脂质体,研究多种分子功能 整体膜蛋白(alamethicin)、外周蛋白(melittin)、缬氨酸霉素(valinomycin)、 非肌动蛋白主要与脂质头基团相互作用,很容易合并到四脂质结构中。 各种活细胞类型的生长不受MPL的影响,当MPL脂质体注射到小鼠体内时,除了增加行为活动外,没有检测到任何药理学或毒性作用。 标记的MPL脂质体可迅速从循环中清除。  

This product is a tetraether monosaccharide phospholipid of high purity and is the main phospholipid (MPL) of Thermoplasma acidophilum. It contains a glycerophosphate and a gulosyl pyranoside monosaccharide linked via a tetrather chain. The MPL is largely responsible for T. acidophilum’s ability to survive in low pH (1-2) and high temperatures (55- 59°C)1 and constitutes almost half of the total lipids.2 MPL is useful for making liposomes to study various molecular functions.3 It has been found to be valuable in the development and application of model membrane systems on the basis of tetraether lipids as demonstrated by the integral membrane protein alamethicin and the peripheral proteins melittin, valinomycin, and nonactin which interact primarily with lipid head groups and are readily incorporated into the tetraether lipid structures. Growth of various living cell types was not affected by the MPL and when MPL liposomes were injected into mice no pharmacological or toxic effects were detected other than increased behavioural activity. Labeled MPL liposomes were found to be rapidly cleared from the circulation.4

References:
1. H. Shimada et al. “Complete Polar Lipid Composition of Thermoplasma acidophilum HO-62 Determined by High-Performance Liquid Chromatography with Evaporative Light-Scattering Detection” Journal of Bacteriology, Vol. 184:2 pp. 556-563, 2002
2. I. Uda et al. “Characterization of caldarchaetidylglycerol analogs, dialkyl-type and trialkyl-type, from Thermoplasma acidophilum” Lipids, Vol. 35:10 pp. 1155-1157, 2000
3. H.-J. Freisleben et al. “Reconstitution of bacteriorhodopsin and ATP synthase from Micrococcus luteus into liposomes of the purified main tetraether lipid from Thermoplasma acidophilum : proton conductance and light-driven ATP synthesis” Chemistry and Physics of Lipids, Vol. 78:2 pp. 137, 1995
4. H.-J. Freisleben et al. “Toxicity and Biodistribution of Liposomes of the Main Phospholipid from the Archaebacterium Thermoplasma Acidophilum in Mice” Journal of Liposome Research, Vol. 5:1 pp. 215, 1995

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