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Ceramides (mixture)/神经酰胺(混合物)/100403-19-8

Specifications

  • Catalog #:                                 1056

  • Scientific Name:Ceramides

  • Common Name:Ceramides with hydroxy and non-hydroxy acyl groups

  • Empirical Formula:C42H83NO4 (2-hydroxylignoceroyl)
    Typical fatty acid content

  • CAS#:100403-19-8

  • SDS:View Safety Data Sheet

  • Data Sheet:View Data Sheet

  • Formula Weight:666 (2-hydroxylignoceroyl)

  • Unit:25 mg

  • Solvent:none

  • Source:natural

  • Purity:98+%

  • Analytical Methods:TLC; identity confirmed by MS

  • Natural Source:bovine

  • Solubility:chloroform/methanol, 2:1

  • Physical Appearance:solid

  • Storage:-20°C

  • Dry Ice:No

  • Hazardous:No

  • DESCRIPTION

  • 本品含有含有羟基和非羟基脂肪酸的神经酰胺。神经酰胺是一种鞘氨醇的脂肪酸酰胺。神经酰胺是神经鞘磷脂、鞘糖脂、游离鞘糖苷和脂肪酸合成的前体。鞘氨醇可被磷酸化形成鞘氨醇-1-磷酸。神经酰胺的两种代谢物,磷酸鞘氨酸和葡萄糖酰神经酰胺,产生细胞增殖和其他细胞功能神经酰胺具有多种生物学效应,包括诱导细胞成熟、细胞周期阻滞、细胞晚期分化、细胞衰老和细胞死亡由于这些作用,神经酰胺已被研究用于癌症治疗,并提出了许多潜在的癌症治疗方法其他作用包括在线粒体中产生活性氧(随后是凋亡)和刺激某些蛋白的磷酸化(特别是丝裂原活化蛋白)。它还刺激一些蛋白质磷酸酶(特别是蛋白质磷酸酶2A),使其成为蛋白质活性的重要控制器。2-羟基脂肪酸神经酰胺在神经细胞和表皮细胞中尤为丰富。这些神经酰胺对表皮的渗透屏障功能和膜中的脂质组织很重要。2-羟化作用由脂肪酸2-羟化酶(FA2H或脂肪酸-羟化酶)催化。

  • This product contains ceramides with both hydroxy and non-hydroxy fatty acids. Ceramide is a fatty acid amide of sphingosine. Ceramide functions as a precursor in the synthesis of sphingomyelin, glycosphingolipids, and of free sphingosine and fatty acids. The sphingosine can be phosphorylated to form sphingosine-1-phosphate. Two of ceramide’s metabolites, sphingosine-1-phosphate and glucosylceramide, produce cell proliferation and other cellular functions.1 Ceramide exerts numerous biological effects, including induction of cell maturation, cell cycle arrest, terminal cell differentiation, cell senescence, and cell death.2 Because of these effects ceramide has been investigated for its use in cancer treatment and many potential approaches to cancer therapy have been presented.3 Other effects include producing reactive oxygen in mitochondria (followed by apoptosis) and stimulating phosphorylation of certain proteins (especially mitogen activated protein). It also stimulates some protein phosphatases (especially protein phosphatase 2A) making it an important controller of protein activity. 2-hydroxy fatty acid ceramides are especially abundant in nervous and epidermal cells. These ceramides are important for the permeability barrier function of epidermis and the lipid organization in membranes. The 2- hydroxylation is catalyzed by fatty acid 2-hydroxylase (FA2H or fatty acid alpha-hydroxylase.

  • Application Notes:References:
    1. J. M. L. Hauser et al., J. Biol. Chem. 269, 6803, 1994
    2. N. S. Radin, “Killing tumours by ceramide-induced apoptosis: a critique of available drugs” Biochemical Journal, Vol. 371 pp. 243-256, 2003
    3. N. S. Radin, “Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria” Bioorganic and Medicinal Chemistry, Vol. 11(10) pp. 2123-2142, 2003

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