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5-alpha-Cholestane/5-alpha-胆甾烷/481-21-0

Specifications

  • Catalog #:1115

  • Scientific Name:

    5-alpha-Cholestane

  • Common Name:

    5-alpha-Cholestane

  • Empirical Formula:C27H48

  • CAS#:481-21-0

  • SDS:View Safety Data Sheet

  • Data Sheet:View Data Sheet

  • Formula Weight:373

  • Unit:100 mg

  • Solvent:none

  • Source:synthetic

  • Purity:98+%

  • Analytical Methods:GC

  • Solubility:chloroform, ethyl ether, hexane

  • Physical Appearance:solid

  • Storage:-20°C

  • Dry Ice:No

  • Hazardous:No

Description

Application Notes:

5- -胆甾醇是胆固醇的非羟基氢化形式,可作为固醇研究的内部标准胆固醇是一种对所有动物生命都至关重要的固醇,对膜的通透性和流动性以及许多细胞功能都至关重要。它是一种固醇,既可以在动物体内合成,也可以从饮食中获得。植物甾醇已被发现在肠道内与胆固醇竞争吸收,从而导致胆固醇吸收的减少植物甾醇是植物细胞膜的重要组成部分,在质膜、线粒体外膜和内质网中具有特殊的作用。植物甾醇与鞘糖脂在筏状亚域内结合,可以影响许多细胞功能,包括膜流动性、通透性、膜结合酶的活性、细胞分化、细胞信号传导和细胞增殖。植物甾醇已被广泛用于人类,试图降低胆固醇和治疗某些癌症。

5-alpha-Cholestane is the non-hydroxy, hydrogenated form of cholesterol and is useful as an internal standard for studies involving sterols.1 Cholesterol is a sterol that is essential for all animal life, being critical for membrane permeability and fluidity and for many cellular functions. It is a sterol that is both synthesized in animals and also acquired from the diet. Phytosterols have been found to compete with cholesterol for absorption in the intestinal tract which results in a reduction of cholesterol absorption.2 Plant sterols are important components of membranes and have a particular role in the plasma membrane, mitochondrial outer membrane, and endoplasmic reticulum. Plant sterols will complex with glycosphingolipids in raft-like sub-domains and can affect many cellular functions including membrane fluidity, permeability, activity of membrane-bound enzymes, cellular differentiation, cellular signaling, and cellular proliferation. Plant sterols have been used extensively in humans to attempt to lower cholesterol and treat certain cancers.3

References:
1. R. Iborra et al. “Advanced Glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1” Lipids in Health and Disease, vol. 10 pp. 1-7, 2011
2. R. Ostlund et al. “Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans” Am J Clin Nutr, Vol. 75(6) pp. 1000-1004, 2002
3. A. de Jong, J. Plat, R. Mensink “Metabolic effects of plant sterols and stanols (Review)” Journal of Nutritional Biochemistry, Vol. 14:7 pp. 362-369, 2003

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