lyso-Globoside/溶血红细胞糖苷酯
Specifications
Catalog #:1541
Scientific Name:lyso-Globoside
Common Name:lyso-Gb4; lyso-Globotetrahexosylceramide
Empirical Formula:C44H80N2O22
SDS:View Safety Data Sheet
Data Sheet:View Data Sheet
Formula Weight:989
Unit:1 mg
Source:semisynthetic
Purity:98+%
Analytical Methods:TLC; HPLC; identity confirmed by MS
Solubility:chloroform/methanol/water, 2:1:0.1
Physical Appearance:solid
Storage:-20℃
Dry Ice:No
Hazardous:No
Description
Application notes:
溶栓-球糖苷是鞘氨醇- n -去乙酰化的中性鞘糖脂球形糖苷的类似物。与乙酰化的糖鞘脂相比，溶糖鞘脂具有非常不同的生理功能。球糖苷是红细胞膜中最丰富的中性糖脂，聚集在细胞壁脂筏中。它们参与细胞通讯，增加细胞粘附，并作为受体发挥作用。它是血型p抗原的基本结构。该抗原的缺陷导致抗球蛋白抗体和P血型表型。球形糖苷是多种毒素的受体，包括p -缨状大肠杆菌，人细小病毒B191和白菜蝴蝶的pierisin-1毒素在泰-萨克斯病和山德霍夫病中，由于β -己糖苷酶的缺乏，球蛋白可累积。
lyso-Globoside is the sphingosine-N-deacetylated analog of the neutral glycosphingolipid globoside. lyso-glycosphingolipids can have very different physiological functions compared to their acetylated counterparts. Globoside is the most abundant neutral glycolipid in the erythrocyte membrane, accumulating in lipid rafts of the cell wall. They are involved in cell communication, increase cell adhesion, and function as receptors. It is an essential structure of the blood group P-antigen. A deficiency in this antigen leads to anti-globoside antibodies and the P blood group phenotypes. Globoside is a receptor for multiple toxins including P-fimbriated Escherichia coli, human parvovirus B191 and pierisin-1 toxin from the cabbage butterfly.2 In Tay-Sachs and Sandhoff disease globoside can accumulate due to the deficiency of beta-hexosaminidase.3
Selected References:
1. Boel Lanne et al “Glycoconjugate Receptors for P-fimbriated Escherichia coli in the Mouse an Animal Model of Urinary Tract Infection” The Journal of Biological Chemistry, Vol. 270 pp. 9017, 1995
.2. Yuko Matsushima-Hibiya “Identification of Glycosphingolipid Receptors for Pierisin-1, a Guanine-specific ADP-ribosylating Toxin from the Cabbage Butterfly” The Journal of Biological Chemistry, Vol. 278 pp. 9972, 2003
3. R. A. Gravel, M. M. Kaback, R. Proia, K. Sandhoff, K. Suzuki, and K. Suzuki. in The Metabolic and Molecular Bases of Inherited Disease (C. R. Scriver, W. S. Sly, B. Childs, A. L. Beaudet, D. Valle, K. W. Kinzler, and B. Vogelstein, eds) pp. 3827–3876, McGraw-Hill Inc., New York, 2001
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