N-Hexadecanoyl-D9 (13,13,14,14,15,15,16,16,16)-monosialoganglioside GM1(NH4+ salt)/N-十六烷酰基-D9 (13,13,14,14,15,15,16,16,16)-单唾液酸神经节苷脂GM1 (NH4+ salt)

Specifications

• Catalog #:2057

• Scientific Name:N-Hexadecanoyl-D₉ (13,13,14,14,15,15,16,16,16)-monosialoganglioside GM₁(NH₄⁺ salt)

• Common Name:GM₁-D₉; N-CD₉-Palmitoyl-GM₁

• Empirical Formula:C₇₁H₁₁₈D₉N₃O₃₁•NH₃

• SDS:View Safety Data Sheet

• Data Sheet:View Data Sheet

• Formula Weight:1528 + NH₃

• Unit:500 µg

• Source:semisynthetic, bovine

• Purity:98+%

• Analytical Methods:TLC; identity confirmed by MS

• Solubility:chloroform/methanol/water, 2:1:0.2

• Physical Appearance:solid

• Storage:-20℃

• Dry Ice:No

• Hazardous:No

Description

Application Notes:

神经节苷脂是酸性的鞘糖脂，在细胞膜的外层形成脂筏，特别是在中枢神经系统的神经元细胞中。它们参与细胞增殖、分化、黏附、信号转导、细胞间相互作用、肿瘤发生和转移。神经节苷脂的积累与多种疾病有关，包括泰-萨克斯病和山德霍夫病。对神经节苷脂的自身免疫反应可导致格林-巴利综合征。GM1通过与神经生长因子(NGF)的高亲和力酪氨酸激酶型受体Trk直接紧密结合，刺激神经元萌发，增强神经生长因子(NGF)的作用。它是霍乱毒素在细胞表面的特异性受体。

Gangliosides¹ are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.² They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.³ The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GM₁  stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF) by directly and tightly associating with Trk, the high-affinity tyrosine kinase-type receptor for NGF. It is the specific cell surface receptor for cholera toxin.⁴

References:
1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
2. T. Kolter, R. Proia, K. Sandhoff, Combinatorial Ganglioside Biosynthesis. J. Biol. Chem., July Vol. 277, No. 29, pp. 25859-25862, 2002
3. S. Birkle, G. Zeng, L. Gao, R. K. Yu, and J. Aubry. Role of tumor-associated gangliosides in cancer progression. Biochimie, 85, 455–463, 2003
4. C. E. Miller, J. Majewski, R. Faller, S. Satija, and T. L. Kuhl, Cholera Toxin Assault on Lipid Monolayers Containing Ganglioside GM1. Biophysj., June Vol. 86(6), 3700–3708, 2004