rac-beta-Tocopherol/rac-beta-生育酚/148-03-8
Specifications
Catalog #:1071
Scientific Name:rac-beta-Tocopherol
Common Name:5,8-Dimethyltocol
Empirical Formula:C28H48O2
CAS#:148-03-8
SDS:View Safety Data Sheet
Data Sheet:View Data Sheet
Formula Weight:417
Unit:50 mg/ml, 1ml
Solvent:hexane
Source:synthetic
Purity:TLC 95%, GC 98%, HPLC 98%
Analytical Methods:TLC, GC, HPLC; identity confirmed by MS
Solubility:methanol, ethanol, hexane, chloroform
Physical Appearance:liquid
Storage:-20℃
Dry Ice:No
Hazardous:Yes
Description
Application Notes:
β-生育酚是维生素E的一种形式，以其抗氧化活性而闻名。1,2 β-生育酚由于只有一个正对酚羟基的甲基，在体内的抗氧化活性略低于α -生育酚，α -生育酚有两个正对甲基。维生素E通过向脂质自由基提供酚氢来抑制脂质氧化体内抗氧化活性通常为alpha>beta>delta>gamma，但抗氧化效力可能取决于各种化学和物理情况原甲基取代基对生育酚的抗氧化活性起着重要作用，而植基尾对其在生物膜中的位置至关重要。维生素E的抗氧化特性可以延缓唐氏综合征患者的记忆丧失，这是由于维生素E保护了超氧化物歧化酶过量活动引起的有害氧化。维生素E仅在植物、藻类和一些蓝藻中天然产生，因此是人类和动物的重要膳食营养物质。
beta-tocopherol is one of the forms of vitamin E, which is well known for its antioxidant activity.1,2 beta-tocopherol, due to its having only one methyl group ortho to the phenolic hydroxyl group, has slightly less antioxidant activity in vivo than alpha-tocopherol which has two ortho-methyl groups. Vitamin E inhibits lipid oxidation by donating its phenolic hydrogen to lipid free radicals.3 Antioxidant activity in vivo is normally alpha>beta>delta>gamma but the antioxidant potency may depend on various chemical and physical situations.4 The ortho-methyl substitution of the chroman head plays a vital role in the antioxidant activity of tocopherols while the phytyl tail is very important for proper positioning in the biomembranes. The antioxidant properties of vitamin E may delay memory loss in Down’s syndrome patients due to their protection from harmful oxidation caused by excess activity of Superoxide dismutase. Vitamin E is only naturally produced in plants, algae, and some cyanobacteria and is therefore an important dietary nutrient for humans and animals.
References:
1. Afaf Kamal-Eldin and Lars-Ake Appelqvist The chemistry and antioxidant properties of tocopherols and tocotrienols, Lipids, July; 31 (7): 671-701, 1996
2. G. W. Burton, and M. G. Traber Vitamin E: Antioxidant Activity, Biokinetics, and Bioavailability, Annual Review of Nutrition, July Vol. 10: 357-382, 1990
3. G. W. Burton and K. Ingold Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro, U. J. Am. Chem. Soc., 103, 6472-6477, 1981
4. Anchalee Sirikhachornkit, Jai W. Shin, Irene Baroli, and Krishna K. Niyogi Replacement of a -tocopherol by ß -tocopherol enhances resistance to photo-oxidative stress in a xanthophyll-deficient strain of Chlamydomonas reinhardtii, Eukaryotic Cell, doi:10.1128, 2009
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