rac-5,7-Dimethyltocol/rac-5,7-二甲基母育酚/493-35-6
Specifications
Catalog #:1074
Scientific Name:rac-5,7-Dimethyltocol
Common Name:rac-5,7-Dimethyltocol
Empirical Formula:C28H48O2
CAS#:493-35-6
SDS:View Safety Data Sheet
Data Sheet:View Data Sheet
Formula Weight:417
Unit:50 mg/ml 1ml
Solvent:hexane
Source:synthetic
Purity:TLC 95% ; GC 98%; HPLC 98%
Analytical Methods:TLC; GC; HPLC; identity confirmed by MS
Solubility:hexane, ethyl ether, chloroform, alcohols
Physical Appearance:liquid
Storage:-20℃
Dry Ice:No
Hazardous:Yes
Description
Application Notes:
rac-5,7-二甲基母育酚在结构上与生育酚(维生素E)和生育三烯醇非常相似，但不是天然发现的，因此是生育酚和生育三烯醇质谱、HPLC和GC分析的理想内部标准。在实验过程中发现，rac-5,7-二甲基母育酚的功能不同于生育酚和生育三烯醇。例如，与天然生育酚相比，rac- 5,7-二甲基母育酚的抗氧化活性较低，然而对细胞微黏度的贡献也较其他生育酚低，已有研究表明，rac-5,7-二甲基母育酚(像大多数其他生育酚一样，但不是母育酚)可以在体外转化为α -生育酚。
This synthetic product is very similar in structure to tocopherol (vitamin E) and tocotrienol but is not found naturally and is therefore an ideal MS, HPLC, and GC internal standard for tocopherols and tocotrienols.1 In experimental procedures it has been found that the functionality of rac-5,7-dimethyltocol is different from tocopherols and tocotrienols. For example, rac- 5,7-dimethyltocol has less antioxidant activity than natural tocopherols2 and contributes less to cellular microviscostiy than other tocopherols.3 However, it has been shown that rac-5,7-dimethyltocol (like most other tocopherols but not tocol) can be converted in vitro into alpha-tocopherol.
References:
1. J. Kramer “A rapid method for the determination of vitamin E forms in tissues and diet by high-performance liquid chromatography using a normal-phase diol column” Lipids, Vol.32:3 pp. 323-330 1997
2. H. Olcott and J. Van der Veen “Comparison of antioxidant activities of tocol and its methyl derivatives” Lipids, Vol. 3:4 pp. 331-334, 1968
3. S. Urano et al. “Vitamin E: Inhibition of Retinol-induced Hemolysis and Membrane-stabilizing Behavior” Journal of Biological Chemistry, Vol. 267:26 pp. 18365-18370, 1992
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