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rac-Tocol/rac-母育酚/119-98-2

Specifications

  • Catalog #:1797

  • Scientific Name:rac-Tocol

  • Common Name:Tocol

  • Empirical Formula:C26H44O2

  • CAS#:119-98-2

  • SDS:View Safety Data Sheet

  • Data Sheet:View Data Sheet

  • Formula Weight:389

  • Unit:50 mg/ml, 1 ml

  • Solvent:hexane

  • Source:synthetic

  • Purity:TLC, 95%; GC, 98%; HPLC, 98%

  • Analytical Methods:TLC, GC, HPLC, identity confirmed by MS

  • Solubility:hexane, methanol, ethanol

  • Physical Appearance:liquid

  • Storage:-20°C

  • Dry Ice:No

  • Hazardous:Yes

Description

Application Notes:

rac-母育酚在结构上与生育酚(维生素E)和生育三烯醇非常相似,但不是天然发现的,因此是生育酚和生育三烯醇质谱、HPLC和GC分析的理想内部标准。在实验过程中,已经发现母育酚的功能不同于生育酚和生育三烯醇。天然α -生育酚对红细胞溶血有较好的抑制作用,而母育酚对溶血的影响很小。母育酚对提高大鼠肝脏PC脂质体微黏度也无明显作用,而α -生育酚具有较好的作用。尽管大多数生育酚底物(包括rac-5,7-二甲基生育酚)在体外能转化为生育酚,但母育酚却不能,使其在生命系统中成为一种稳定的合成化合物。

This synthetic product is very similar in structure to tocopherol (vitamin E) and tocotrienol but is not found naturally and is therefore an ideal MS, HPLC, and GC internal standard for tocopherols and tocotrienols.1 In experimental procedures it has been found that the functionality of tocol is different from tocopherols and tocotrienols. Whereas natural alpha-tocopherol is effective in suppressing erythrocyte hemolysis tocol has very little effect on hemolysis.2 Tocol has also been found to be ineffective in increasing the microviscosity of rat liver PC liposomes while alpha-tocopherol showed good effectiveness. Whereas most tocopherol substrates (including rac-5,7-dimethyltocol) are converted in vitro into tocopherol, tocol is not, making it a stable synthetic compound in living systems.3

References:
1. T. Sontag and R. Parker “Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol omega –hydroxylase” Journal of Lipid Research, Vol. 48 pp. 1090-1098, 2007
2. K. Mukaill et. al “Vitamin E: Inhibition of Retinol-induced Hemolysis and Membrane-stabilizing Behavior” Journal of Biological Chemistry, Vol. 267:26 pp.18365-18370, 1992
3. K. Thimann Vitamins and Hormones Vol. 34 pp. 91

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