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alpha-Tocotrienol/alpha-生育三烯酚/58864-81-6

Specifications

  • Catalog #:2109

  • Scientific Name:alpha-Tocotrienol

  • Common Name:3,4-Dihyro-2,5,7,8-tetramethyl-2R-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl)]-2H-1-benzopyran-6-ol

  • Empirical Formula:C29H44O2

  • CAS#:58864-81-6

  • SDS:View Safety Data Sheet

  • Data Sheet:View Data Sheet

  • Formula Weight:425

  • Unit:25 mg

  • Solvent:none

  • Source:natural

  • Purity:98+%

  • Analytical Methods:TLC, GC, HPLC, identity confirmed by MS

  • Natural Source:plant

  • Solubility:hexane, ethyl ether, ethanol

  • Physical Appearance:liquid

  • Storage:-20°C

  • Dry Ice:No

  • Hazardous:No

Description

Application Notes:

维生素E由四种生育酚和四种生育三烯醇组成,具有重要而深远的生物活性。这些必需的脂类含有一个共同的色酚环和一个饱和的(生育酚)或不饱和的(生育三烯醇)侧链。根据色酚环上甲基的数量和位置以及饱和或不饱和侧链的存在,维生素E的8种常见亚型(-、-、-和-生育酚和-、-、-生育三烯醇)被区分。维生素E维生素通常存在于蔬菜、水果、种子、坚果、谷物和油类中,它们以不同的比例存在。tocotrienols给他们的不饱和侧链与生育酚物理性质不同,如穿过细胞膜的能力增加双分子层(1),维生素E已成为众所周知的作为一种抗氧化剂,在降低胆固醇和其他脂肪,作为神经保护和抗癌剂,在心血管疾病的保护方面。大多数维生素E补充剂只含有(许多研究使用)α -生育酚;然而,上述几种生物效应大多或只存在于其他维生素中,因此将它们纳入未来的研究至关重要。事实上,生育三烯醇一般比生育酚具有更大的生理功能(2),甚至可能被过量的α -生育酚补充剂抑制(3)。Matreya很高兴为您的研究需要提供这种高度纯化的α -生育三烯醇标准品。

Vitamin E consists of four tocopherols and four tocotrienols that demonstrate important and far reaching biological activities. These essential lipids contain a common chromanol ring and either a saturated (tocopherol) or unsaturated (tocotrienol) side chain. The eight common vitamin E isoforms (alpha-, beta-, gamma-, and delta-tocopherols and alpha-, beta-, gamma-, and delta-tocotrienols) are differentiated based on the number and position of methyl groups on the chromanol ring and the presence of a saturated or unsaturated side chain. The vitamin E vitamers are commonly found in vegetables, fruits, seeds, nuts, grains and oils, where they exist in various ratios with each other. The unsaturated side chain in tocotrienols gives them physical properties different from tocopherols, such as an increased ability to cross the cell membrane bilayer (1). Vitamin E has become well known for its role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection. Most vitamin E supplements contain (and many studies use) only alpha-tocopherol; However, several of the above biological effects are mostly or exclusively found in the other vitamers, making it critical for them to be included in future research. Indeed, the tocotrienols in general may have greater physiological functions than tocopherols (2) and may even be inhibited by an unbalanced excess of alpha-tocopherol supplements (3). Matreya is pleased to offer this highly purified alpha-tocotrienol standard for your research needs.

References:
1. Ahn, K., et al. (2007) J Biol Chem. 282:809-820
2. Kannappan, R., et al. (2010) J Biol Chem. 285:33520
3. Tan, B., (2005) The Journal of the American Neutricutical Association 8(1):35

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